Modulation of spike clustering by NMDA receptors and neurotensin in rat supraoptic nucleus neurons
نویسندگان
چکیده
منابع مشابه
Activity-dependent feedback modulation of spike patterning of supraoptic nucleus neurons by endogenous adenosine.
Neuropeptide secretion from the dendrites of hypothalamic magnocellular supraoptic nucleus (SON) neurons contributes to the regulation of neuronal activity patterning, which ultimately determines their peptide output from axon terminals in the posterior pituitary gland. SON dendrites also secrete a number of other neuromodulators, including ATP. ATP degrades to adenosine in the extracellular sp...
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We studied the effects of activation of the metabotropic glutamate receptors on intrinsic currents of magnocellular n urons of the supraoptic nucleus (SON) with whole cell patch-clamp and conventional intracellular recordings in coronal slices (400 micron) of the rat hypothalamus. Trans-(+/-)-1-amino-1,3-cyclopentane dicarboxylic acid (trans-ACPD, 10-100 microM), a broad-spectrum metabotropic g...
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Magnocellular neurons of the supraoptic nucleus release the neuropeptides oxytocin and vasopressin from their dendrites to regulate their synaptic inputs. This study aims to determine the cellular mechanism by which vasopressin modulates excitatory synaptic transmission. Presumably by electroporation through perforated patch, we were able to successfully introduce biocytin into cells in which w...
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The suprachiasmatic nucleus (SCN) is the site of a putative pacemaking oscillator for the regulation of circadian rhythms in mammals (Nishino et al. 1976; Rusak and Zucker, 1979; Turek, 1985; Mei jer and Rietveld, 1989). The SCN receives visual information from the retinohypothalamic tract (RHT) (Moore, 1973; Millhouse, 1977; Pickard, 1982) and indirectly via the retino-geniculo-supra chiasmati...
متن کاملHistamine suppresses non-NMDA excitatory synaptic currents in rat supraoptic nucleus neurons.
Whole cell patch-clamp recordings were obtained from supraoptic neurons to investigate the effects of histamine on excitatory postsynaptic currents evoked by electrical stimulation of areas around the posterior supraoptic nucleus. When cells were voltage-clamped at -70 mV, evoked excitatory postsynaptic currents had amplitudes of 88.4 +/- 9.6 pA and durations of 41.1 +/- 3.0 ms (mean +/- SE; n ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2014
ISSN: 0022-3751,1469-7793
DOI: 10.1113/jphysiol.2014.275602